Splenic CD19-CD35+B220+ cells function as an inducer of follicular dendritic cell network formation

Takaya Murakami, Xin Chen, Koji Hase, Ayako Sakamoto, Chie Nishigaki, Hiroshi Ohno

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Follicular dendritic cells (FDCs) form a reticular FDC network in the lymphoid follicle that is essential for the retention and presentation of native antigens in the form of antigen-antibody immune complexes (ICs) to B cells during secondary immune response. Although the presence of migrating precursors of FDCs has been hypothesized, their entity has not been elucidated. Here we report the identification of murine splenic CD19-CD11c -CD35+B220+ cells as an inducer of FDC network formation. We demonstrated that CD19--CD11c-CD35 +B220+ cells, together with stromal cells, had the remarkable ability to form lymphoid-follicle-like structures that contained B220+FDC-M1+ reticular cells originally derived from CD19--CD11c-CD35+B220+ cells in the CD35+ reticulum. Our results indicate that CD19-CD11c -CD35+B220+ cells function as an inducer of FDC network formation and that the interaction between CD19-CD11c -CD35+B220+ cells and stromal cells is required to initiate lymphoid follicle formation.

本文言語English
ページ(範囲)1215-1224
ページ数10
ジャーナルBlood
110
4
DOI
出版ステータスPublished - 2007 8 15
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 免疫学
  • 血液学
  • 細胞生物学

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