Spontaneous growth hormone secretion in healthy prepubertal children of normal stature

Tomonobu Hasegawa, Y. Hasegawa, T. Yokoyama, S. Koto, Y. Tsuchiya

研究成果: Article

5 引用 (Scopus)

抄録

To evaluate the dynamics of growth hormone (GH) secretion in healthy prepubertal children of normal stature, we determined spontaneous GH secretion by measuring GH every 30 min in 21 Japanese subjects, age: 5.4±2.3 (1.6~10.6) years; height: -1.4±1.1 (- 1.98~ 1.77) SD. The 24-h mean GH concentration was 4.8±1.5 ng/ml. The 24-h mean GH was similar in boys and girls (mean±SD: 4.8±1.7 vs 4.7±1.1 ng/ml). No correlation was found between chronological age and the 24-h mean GH. The 24-h mean GH was closely correlated with GH pulse amplitude (r = 0.94; P<0.001), but not with the number of GH pulses. The 24-h mean GH was also highly correlated with 3-h mean GH after sleep and 3-h peak GH after sleep (r = 0.86; P<0.001 and r = 0.72; P<0.001, respectively). Our data suggest that in healthy prepubertal children of normal stature, (1) spontaneous GH secretion is independent of sex and age. (2) the amount of spontaneous GH secretion is controlled by pulse amplitude, not by number of pulses. (3) 3-h mean GH and 3-h peak GH after sleep might represent 24-h total spontaneous GH secretion.

元の言語English
ページ(範囲)9-12
ページ数4
ジャーナルEndocrinologia Japonica
39
発行部数1
出版物ステータスPublished - 1992
外部発表Yes

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Growth Hormone
Sleep

ASJC Scopus subject areas

  • Endocrinology

これを引用

Spontaneous growth hormone secretion in healthy prepubertal children of normal stature. / Hasegawa, Tomonobu; Hasegawa, Y.; Yokoyama, T.; Koto, S.; Tsuchiya, Y.

:: Endocrinologia Japonica, 巻 39, 番号 1, 1992, p. 9-12.

研究成果: Article

Hasegawa, T, Hasegawa, Y, Yokoyama, T, Koto, S & Tsuchiya, Y 1992, 'Spontaneous growth hormone secretion in healthy prepubertal children of normal stature', Endocrinologia Japonica, 巻. 39, 番号 1, pp. 9-12.
Hasegawa, Tomonobu ; Hasegawa, Y. ; Yokoyama, T. ; Koto, S. ; Tsuchiya, Y. / Spontaneous growth hormone secretion in healthy prepubertal children of normal stature. :: Endocrinologia Japonica. 1992 ; 巻 39, 番号 1. pp. 9-12.
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AU - Tsuchiya, Y.

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