Spontaneous growth hormone secretion in healthy prepubertal children of normal stature

T. Hasegawa, Y. Hasegawa, T. Yokoyama, S. Koto, Y. Tsuchiya

研究成果: Article査読

5 被引用数 (Scopus)

抄録

To evaluate the dynamics of growth hormone (GH) secretion in healthy prepubertal children of normal stature, we determined spontaneous GH secretion by measuring GH every 30 min in 21 Japanese subjects, age: 5.4±2.3 (1.6~10.6) years; height: -1.4±1.1 (- 1.98~ 1.77) SD. The 24-h mean GH concentration was 4.8±1.5 ng/ml. The 24-h mean GH was similar in boys and girls (mean±SD: 4.8±1.7 vs 4.7±1.1 ng/ml). No correlation was found between chronological age and the 24-h mean GH. The 24-h mean GH was closely correlated with GH pulse amplitude (r = 0.94; P<0.001), but not with the number of GH pulses. The 24-h mean GH was also highly correlated with 3-h mean GH after sleep and 3-h peak GH after sleep (r = 0.86; P<0.001 and r = 0.72; P<0.001, respectively). Our data suggest that in healthy prepubertal children of normal stature, (1) spontaneous GH secretion is independent of sex and age. (2) the amount of spontaneous GH secretion is controlled by pulse amplitude, not by number of pulses. (3) 3-h mean GH and 3-h peak GH after sleep might represent 24-h total spontaneous GH secretion.

本文言語English
ページ(範囲)9-12
ページ数4
ジャーナルEndocrinologia Japonica
39
1
DOI
出版ステータスPublished - 1992
外部発表はい

ASJC Scopus subject areas

  • 内分泌学
  • 工学(全般)

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