SPR sensor signal amplification based on dye-doped polymer particles

Hirokazu Komatsu, Makiko Miyachi, Eiji Fujii, Daniel Citterio, Koji Yamada, Yoshinobu Sato, Kazuyoshi Kurihara, Haruma Kawaguchi, Koji Suzuki

研究成果: Article査読

18 被引用数 (Scopus)

抄録

A novel amplification method was prepared based on dye-doped polymer particles for SPR signals originating from antigen-antibody (BSA-anti-BSA) interactions. Coloring the particles enhances the change of SPR signals based on the change of the imaginary part of the refractive index. The signal amplification effect in the reflectance mode was 31-fold stronger compared to the effect obtained with white latex particles and the combined amplification effect due to the presence of polymer particles and the colorant was over 100-fold compared to non-amplified SPR signals originating from BSA-anti-BSA interactions. The amplification method based on the dye-doped particles is widely applicable for the analysis of antibody-antigen interactions and DNA interactions at low concentrations.

本文言語English
ページ(範囲)150-155
ページ数6
ジャーナルScience and Technology of Advanced Materials
7
2
DOI
出版ステータスPublished - 2006 3月
外部発表はい

ASJC Scopus subject areas

  • 材料科学(全般)

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