Spreading depression as a preclinical model of migraine

Andrea M. Harriott, Tsubasa Takizawa, David Y. Chung, Shih Pin Chen

研究成果: Review article

3 引用 (Scopus)

抄録

Spreading depression (SD) is a slowly propagating wave of near-complete depolarization of neurons and glial cells across the cortex. SD is thought to contribute to the underlying pathophysiology of migraine aura, and possibly also an intrinsic brain activity causing migraine headache. Experimental models of SD have recapitulated multiple migraine-related phenomena and are considered highly translational. In this review, we summarize conventional and novel methods to trigger SD, with specific focus on optogenetic methods. We outline physiological triggers that might affect SD susceptibility, review a multitude of physiological, biochemical, and behavioral consequences of SD, and elaborate their relevance to migraine pathophysiology. The possibility of constructing a recurrent episodic or chronic migraine model using SD is also discussed.

元の言語English
記事番号45
ジャーナルJournal of Headache and Pain
20
発行部数1
DOI
出版物ステータスPublished - 2019 5 2

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Migraine Disorders
Optogenetics
Neuroglia
Epilepsy
Theoretical Models
Neurons
Brain

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine

これを引用

Harriott, A. M., Takizawa, T., Chung, D. Y., & Chen, S. P. (2019). Spreading depression as a preclinical model of migraine. Journal of Headache and Pain, 20(1), [45]. https://doi.org/10.1186/s10194-019-1001-4

Spreading depression as a preclinical model of migraine. / Harriott, Andrea M.; Takizawa, Tsubasa; Chung, David Y.; Chen, Shih Pin.

:: Journal of Headache and Pain, 巻 20, 番号 1, 45, 02.05.2019.

研究成果: Review article

Harriott, AM, Takizawa, T, Chung, DY & Chen, SP 2019, 'Spreading depression as a preclinical model of migraine', Journal of Headache and Pain, 巻. 20, 番号 1, 45. https://doi.org/10.1186/s10194-019-1001-4
Harriott, Andrea M. ; Takizawa, Tsubasa ; Chung, David Y. ; Chen, Shih Pin. / Spreading depression as a preclinical model of migraine. :: Journal of Headache and Pain. 2019 ; 巻 20, 番号 1.
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