Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness

Hiromasa Inoue, Reiko Kato, Satoru Fukuyama, Atsushi Nonami, Kouji Taniguchi, Koichiro Matsumoto, Takako Nakano, Miyuki Tsuda, Mikiko Matsumura, Masato Kubo, Fumihiko Ishikawa, Byoung Gon Moon, Kiyoshi Takatsu, Yoichi Nakanishi, Akihiko Yoshimura

研究成果: Article

86 引用 (Scopus)

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T helper 2 cytokines, including interleukin (IL)-4, IL-5, and IL-13, play a critical role in allergic asthma. These cytokines transmit signals through the Janus kinase/signal transducer and activator of transcription (STAT) and the Ras-extracellular signal-regulated kinase (ERK) signaling pathways. Although the suppressor of cytokine signaling (SOCS) family proteins have been shown to regulate the STAT pathway, the mechanism regulating the ERK pathway has not been clarified. The Sprouty-related Ena/VASP homology 1-domain-containing protein (Spred)-1 has recently been identified as a negative regulator of growth factor-mediated, Ras-dependent ERK activation. Here, using Spred-1 -deficient mice, we demonstrated that Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness, without affecting helper T cell differentiation. Biochemical assays indicate that Spred-1 suppresses IL-5-dependent cell proliferation and ERK activation. These data indicate that Spred-1 negatively controls eosinophil numbers and functions by modulating IL-5 signaling in allergic asthma.

元の言語English
ページ(範囲)73-82
ページ数10
ジャーナルJournal of Experimental Medicine
201
発行部数1
DOI
出版物ステータスPublished - 2005 1 3
外部発表Yes

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

これを引用

Inoue, H., Kato, R., Fukuyama, S., Nonami, A., Taniguchi, K., Matsumoto, K., Nakano, T., Tsuda, M., Matsumura, M., Kubo, M., Ishikawa, F., Moon, B. G., Takatsu, K., Nakanishi, Y., & Yoshimura, A. (2005). Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness. Journal of Experimental Medicine, 201(1), 73-82. https://doi.org/10.1084/jem.20040616