Standard versus long-term prednisolone with Sairei-to for initial therapy in childhood steroid-responsive nephrotic syndrome: A prospective controlled study

Norishige Yoshikawa, Hiroshi Ito, Yasuo Takekoshi, Masataka Honda, Midori Awazu, Kazumoto Iijima, Hajime Nakamura, Yoshiki Seino, Nobuaki Takeda, Shinzaburo Hattori, Ichiro Matsuda

研究成果: Article査読

18 被引用数 (Scopus)

抄録

The most appropriate initial treatment for children with steroid- responsive nephrotic syndrome is controversial. Initial treatment with 18- week prednisolone and the Chinese herbal medicine, Sairei-to, may prevent subsequent relapse. To determine whether similar results can be obtained with a combination of just initial 8-week prednisolone and Sairei-to, we compared the effects of such treatment with those of treatment with 18-week prednisolone and Sairei-to in 196 children with steroid-responsive nephrotic syndrome. The patients were randomly assigned to receive 8-week (group 1) or 18-week (group 2) prednisolone for the initial therapy. All patients received Sairei-to for 2 years in addition to prednisolone. Eighty-eight of the 98 patients in group 1 and 83 of the 98 patients in group 2 completed their trial. At entry, the two groups of patients did not differ in their clinical and laboratory findings. During the 2-year trial, 62 group 1 patients (70%) and 54 group 2 patients (65%) had relapses, and 19 group 1 patients (21%) and 20 group 2 patients (24%) had frequent relapses. The present study demonstrates that a combination of initial 8-week prednisolone and 2-year Sairei-to is effective in children with steroid-responsive nephrotic syndrome.

本文言語English
ページ(範囲)587-590
ページ数4
ジャーナルJapanese Journal of Nephrology
40
8
出版ステータスPublished - 1998

ASJC Scopus subject areas

  • 腎臓病学

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