TY - JOUR
T1 - Status of patients who underwent uninephrectomy in adulthood more than 20 years ago
AU - Ohishi, Akira
AU - Suzuki, Hiromichi
AU - Nakamoto, Hidetomo
AU - Katsumata, Hiroshige
AU - Hayashi, Kouichi
AU - Ryuzaki, Munekazu
AU - Kumagai, Kazuhiro
AU - Furukawa, Tomohiro
AU - Ichihara, Atsuhiro
AU - Saruta, Takao
AU - Higashi, Fuyuhiko
AU - Marumo, Ken
PY - 1995/12
Y1 - 1995/12
N2 - We investigated the status of patients without systemic diseases who had undergone uninephrectomy for unilateral renal diseases in adulthood more than 20 years ago at Tokyo Denryoku Hospital. There were 21 participants (mean age ± SD, 58.6 ± 8.0 years) who fulfilled these criteria. The average interval since nephrectomy was 27.9 ± 6.2 years. The mean current creatinine clearance was 88.5 ± 21.2 mL/min/1.73 m2, which is 92.9% of that in healthy age- and sex-matched controls with two kidneys. The 24-hour urine protein excretion in these patients was only slightly higher than in the controls (214 ± 190 mg v 119 ± 62 mg, P = NS). Age at nephrectomy, length of time with a single kidney, or sex had little effect on the remnant renal functions. There was a positive correlation between current mean arterial pressure and serum creatinine (r = 0.44, P < 0.05). Patients who developed hypertension after uninephrectomy had a family history of hypertension more frequently than those with normotension (86% v 29%, P < 0.05). We conclude that (1) renal function after compensatory hyperfiltration of more than 20 years due to uninephrectomy for unilateral renal diseases in adulthood is well maintained, although hypertension has a considerable effect on the renal functions, and that (2) family history of hypertension plays a key role in determining the incidence of hypertension even in the uninephrectomized patients.
AB - We investigated the status of patients without systemic diseases who had undergone uninephrectomy for unilateral renal diseases in adulthood more than 20 years ago at Tokyo Denryoku Hospital. There were 21 participants (mean age ± SD, 58.6 ± 8.0 years) who fulfilled these criteria. The average interval since nephrectomy was 27.9 ± 6.2 years. The mean current creatinine clearance was 88.5 ± 21.2 mL/min/1.73 m2, which is 92.9% of that in healthy age- and sex-matched controls with two kidneys. The 24-hour urine protein excretion in these patients was only slightly higher than in the controls (214 ± 190 mg v 119 ± 62 mg, P = NS). Age at nephrectomy, length of time with a single kidney, or sex had little effect on the remnant renal functions. There was a positive correlation between current mean arterial pressure and serum creatinine (r = 0.44, P < 0.05). Patients who developed hypertension after uninephrectomy had a family history of hypertension more frequently than those with normotension (86% v 29%, P < 0.05). We conclude that (1) renal function after compensatory hyperfiltration of more than 20 years due to uninephrectomy for unilateral renal diseases in adulthood is well maintained, although hypertension has a considerable effect on the renal functions, and that (2) family history of hypertension plays a key role in determining the incidence of hypertension even in the uninephrectomized patients.
KW - Uninephrectomy
KW - family history of hypertension
KW - hypertension
KW - remnant renal function
KW - unilateral renal disease
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U2 - 10.1016/0272-6386(95)90052-7
DO - 10.1016/0272-6386(95)90052-7
M3 - Article
C2 - 7503062
AN - SCOPUS:0028882804
VL - 26
SP - 889
EP - 897
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
SN - 0272-6386
IS - 6
ER -