Stem cell theory for the pathogenesis of endometriosis

Tetsuo Maruyama, Yasunori Yoshimura

研究成果: Article査読

32 被引用数 (Scopus)

抄録

Proposed hypothetical causes of endometriosis include retrograde menstruation, lymphatic and vascular metastasis, iatrogenic direct implantation, coelomic metaplasia, embryonic rest, and mesenchymal cell differentiation (induction). Each theory, individually, fails to account for all types of endometriotic lesions, thereby implicating combined and/or type-specific mechanisms. Recent evidence supports the presence of endometrial stem/progenitor cells and their possible involvement in eutopic endometrial regeneration and differentiation. Thus an additional novel mechanism for the origin of endometriotic lesions is that they arise from ectopic endometrial stem/progenitor cells.

本文言語English
ページ(範囲)2754-2763
ページ数10
ジャーナルFrontiers in Bioscience - Elite
4 E
8
出版ステータスPublished - 2012 6 1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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