Stem Cells Expressing Matrix Metalloproteinase-13 mRNA Appear during Regression Reversal of Hepatic Cirrhosis

Tetsu Watanabe, Maki Niioka, Shigenari Hozawa, Yoshihiko Sugioka, Masao Arai, Katsuya Maruyama, Hideyuki Okano, Isao Okazaki

研究成果: Chapter

5 被引用数 (Scopus)

抄録

This chapter describes a mechanism that underlies the degradation of newly formed fibrous bands in CCl4-induced liver fibrosis and cirrhosis and demonstrates that neural progenitor cells derived from hematopoietic stem cells express interstitial collagenase in the recovery phase of experimental cirrhosis. It also discusses the availability of hematopoietic stem cells for the treatment of human liver fibrosis or cirrhosis. The reversibility of liver fibrosis in patients with alcoholic cirrhosis and alcoholic fatty liver with fibrosis has been observed after alcohol abstinence. Histologically documented reversibility of liver fibrosis in alcoholic liver diseases was closely correlated with a decrease in serum fibrosis markers of type IV collagen. It is now generally accepted that reversibility of liver fibrosis or cirrhosis occurs under some conditions if the cause of liver damage is removed or adequately treated.

本文言語English
ホスト出版物のタイトルExtracellular Matrix and The Liver
ホスト出版物のサブタイトルApproach to Gene Therapy
出版社Elsevier Inc.
ページ361-388
ページ数28
ISBN(電子版)9780080531502
ISBN(印刷版)9780125252515
DOI
出版ステータスPublished - 2003 2 6

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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