Steps toward safe cell therapy using induced pluripotent stem cells

Hideyuki Okano, Masaya Nakamura, Kenji Yoshida, Yohei Okada, Osahiko Tsuji, Satoshi Nori, Eiji Ikeda, Shinya Yamanaka, Kyoko Miura

研究成果: Review article査読

311 被引用数 (Scopus)

抄録

The enthusiasm for producing patient-specific human embryonic stem cells using somatic nuclear transfer has somewhat abated in recent years because of ethical, technical, and political concerns. However, the interest in generating induced pluripotent stem cells (iPSCs), in which pluripotency can be obtained by transcription factor transduction of various somatic cells, has rapidly increased. Human iPSCs are anticipated to open enormous opportunities in the biomedical sciences in terms of cell therapies for regenerative medicine and stem cell modeling of human disease. On the other hand, recent reports have emphasized the pitfalls of iPSC technology, including the potential for genetic and epigenetic abnormalities, tumorigenicity, and immunogenicity of transplanted cells. These constitute serious safety-related concerns for iPSC-based cell therapy. However, preclinical data supporting the safety and efficacy of iPSCs are also accumulating. In this Review, recent achievements and future tasks for safe iPSC-based cell therapy are summarized, using regenerative medicine for repair strategies in the damaged central nervous system (CNS) as a model. Insights on safety and preclinical use of iPSCs in cardiovascular repair model are also discussed.

本文言語English
ページ(範囲)523-533
ページ数11
ジャーナルCirculation research
112
3
DOI
出版ステータスPublished - 2013 2月 1

ASJC Scopus subject areas

  • 生理学
  • 循環器および心血管医学

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