Stereochemistry of decarboxylation of arylmalonate catalyzed by mutant enzymes

Kenji Miyamoto; Tomomi Tsutsumi; Yosuke Terao; Hiromichi Ohta

doi:10.1246/cl.2007.656

Stereochemistry of decarboxylation of arylmalonate catalyzed by mutant enzymes

Kenji Miyamoto, Tomomi Tsutsumi, Yosuke Terao, Hiromichi Ohta

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研究成果: Article › 査読

6 被引用数 (Scopus)

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The enantiotopos differentiating selectivity of the mutant arylmalonate decarboxylase (S36N/G74C/C188S), which catalyzes asymmetric decarboxylation of arylmethylmalonates to give the corresponding arylpropionates, was revealed to be the same as that of the wild type enzyme, in spite of the fact that two enzymes gave the opposite enantiomer with each other.

本文言語	English
ページ（範囲）	656-657
ページ数	2
ジャーナル	Chemistry Letters
巻	36
号	5
DOI	https://doi.org/10.1246/cl.2007.656
出版ステータス	Published - 2007 5月 5

ASJC Scopus subject areas

化学 (全般)

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10.1246/cl.2007.656

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abstract = "The enantiotopos differentiating selectivity of the mutant arylmalonate decarboxylase (S36N/G74C/C188S), which catalyzes asymmetric decarboxylation of arylmethylmalonates to give the corresponding arylpropionates, was revealed to be the same as that of the wild type enzyme, in spite of the fact that two enzymes gave the opposite enantiomer with each other.",

author = "Kenji Miyamoto and Tomomi Tsutsumi and Yosuke Terao and Hiromichi Ohta",

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AU - Miyamoto, Kenji

AU - Tsutsumi, Tomomi

AU - Terao, Yosuke

AU - Ohta, Hiromichi

PY - 2007/5/5

Y1 - 2007/5/5

N2 - The enantiotopos differentiating selectivity of the mutant arylmalonate decarboxylase (S36N/G74C/C188S), which catalyzes asymmetric decarboxylation of arylmethylmalonates to give the corresponding arylpropionates, was revealed to be the same as that of the wild type enzyme, in spite of the fact that two enzymes gave the opposite enantiomer with each other.

AB - The enantiotopos differentiating selectivity of the mutant arylmalonate decarboxylase (S36N/G74C/C188S), which catalyzes asymmetric decarboxylation of arylmethylmalonates to give the corresponding arylpropionates, was revealed to be the same as that of the wild type enzyme, in spite of the fact that two enzymes gave the opposite enantiomer with each other.

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Stereochemistry of decarboxylation of arylmalonate catalyzed by mutant enzymes

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