Stereochemistry of Hydrogenation of (—)-Dehydrogriseofulvin to (+)-Griseofulvin with a Cell-Free System of Streptomyces cinereocrocatus

Taiko Oda, Yoshihiro Satc

研究成果: Article査読

7 被引用数 (Scopus)

抄録

To elucidate the stereochemistry of the hydrogenation of(-)-dehydrogriseofulvin (la) to (+)- (3a) by Streptomyces cinereocrocatus, we have prepared from the microorganism a cell- system which can transform la to 3a. The hydrogenation activity of the cell-free system increased in the presence of added reduced nicotinamide adenine dinucleotide phosphate (NADPH). The stereochemistry of hydrogenation was determined by 400 MHz proton nuclear magnetic resonance (1H-NMR) analysis of the products obtained by the enzymatic conversion of (—)-[5/-2H]-dehydrogriseofulvin (lb) and also by the enzymatic conversion of h in medium containing deuterium oxide.

本文言語English
ページ(範囲)1077-1082
ページ数6
ジャーナルChemical and Pharmaceutical Bulletin
33
3
DOI
出版ステータスPublished - 1985 1 1

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

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