Stereochemistry of reduction of the C-24,25 double bond in the conversion of desmosterol into cholesterol

Kyoko Takahashi, Kenichiro Hashimoto, Ayako Fujiyama, Junko Yamada, Noriko Kobayashi, Masuo Morisaki, Sayaka Nakano, Noriyuki Hara, Yoshinori Fujimoto

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Feeding of the chemically prepared [24-13C, 24-2H]desmosterol to cell-free systems derived from rat liver and silkworm gut and to cultured cells of Oryza sativa followed by deuterium-decoupled 1H, 13C shift correlation NMR analysis of the biosynthesized cholesterol revealed the stereospecific incorporation of hydrogen atoms from the re-face of the C-24 position of desmosterol.

本文言語English
ページ(範囲)341-344
ページ数4
ジャーナルTetrahedron Letters
44
2
DOI
出版ステータスPublished - 2003 1 6

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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