Stereocontrolled Total Synthesis of Lipoxins As and B5

K. C. Nicolaou, S. E. Webber, J. Ramphal, Y. Abe

研究成果: Article

22 引用 (Scopus)

抜粋

Icosapentaenoic acids and their metabolites are of both nutritional and bio‐medical interest. The title compounds were previously accessible in only very small amounts via biosynthetic routes. Their first total synthesis has now been achieved in good yield and in a stereocontrolled fashion. The key steps were a Pd0–Cu1‐catalyzed coupling of terminal alkynes with vinyl halides to give the icosanoid skeleton and Lindlar hydrogenation to give the Z olefins. (Figure Presented.)

元の言語English
ページ(範囲)1019-1021
ページ数3
ジャーナルAngewandte Chemie International Edition in English
26
発行部数10
DOI
出版物ステータスPublished - 1987 10

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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