Stereoselective approach to (2R,3S)- and (2R,3R)-1,2-(cyclohexylidenedioxy) hept-6-en-3-ol by microbial reduction

Miyu Furuta, Mitsuru Shoji, Takeshi Sugai

研究成果: Letter査読

6 被引用数 (Scopus)

抄録

Among twelve incubated whole-cell yeast strains, two were found to selectively reduce (R)-1,2-(cyclohexylidenedioxy)hept-6-en-3-one, which was derived from d-mannitol. Pichia minuta JCM 3622 and Rhodotorula mucilaginosa NBRC 0889 afforded (2R,3S)-form (97% diastereomeric purity) and (2R,3R)-form (89% diastereomeric purity) of 1,2-(cyclohexylidenedioxy)hept-6-en-3-ols, respectively. As discussed above, the complementary yeast-mediated reduction provided the two diastereomeric glycerol derivatives in high enantiomeric excess.

本文言語English
ページ(範囲)8-11
ページ数4
ジャーナルJournal of Molecular Catalysis B: Enzymatic
82
DOI
出版ステータスPublished - 2012 10

ASJC Scopus subject areas

  • 触媒
  • バイオエンジニアリング
  • 生化学
  • プロセス化学およびプロセス工学

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