Stereoselective glycosylation of 3-deoxy-d-manno-2-octulosonic acid with batch and microfluidic methods

Atsushi Shimoyama, Yukari Fujimoto, Koichi Fukase

研究成果: Article査読

16 被引用数 (Scopus)

抄録

A practical and efficient stereoselective synthesis of 3-deoxy-d-manno-2- octulosonic acid (Kdo) glycoside was achieved using N-trifluoroacetoimidate as the glycosyl donor with both batch and microfluidic methods. The method used a conformationally constrained glycosyl donor, which has a bulky isopropylidene group at the 4,5-O-position. The strained conformation directed the coordination of the acetonitrile solvent, which led to the enhancement of reactivity and -selectivity in the glycosylation.

本文言語English
論文番号U04811ST
ページ(範囲)2359-2362
ページ数4
ジャーナルSynlett
16
DOI
出版ステータスPublished - 2011
外部発表はい

ASJC Scopus subject areas

  • 有機化学

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