Stereospecific analysis of lorazepam in plasma by chiral column chromatography with a circular dichroism-based detector

Hideko Kanazawa, Yuko Kunito, Yoshikazu Matsushima, Shigeo Okubo, Fumiko Mashige

研究成果: Article査読

40 被引用数 (Scopus)

抄録

The chiral separation of lorazepam was achieved on a chiral column with UV and circular dichroism (CD) detection. The good resolution of lorazepam enantiomers was obtained on the column of β-cyclodextrin derivative immobilized silica gel under reversed-phase conditions. The enantiomeric separation and identification of lorazepam were succeeded by CD detector. The method described allows the quantitation of the stereoisomers of lorazepam in human plasma following the administration of a therapeutic dose of the racemic drug. Chiroptical detection is useful for the pharmacokinetic study of chiral drugs. (C) 2000 Elsevier Science B.V.

本文言語English
ページ(範囲)181-188
ページ数8
ジャーナルJournal of Chromatography A
871
1-2
DOI
出版ステータスPublished - 2000 2月 25

ASJC Scopus subject areas

  • 分析化学
  • 生化学
  • 有機化学

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