Stigmastane derivatives from the roots of Vernonia guineensis and their antimicrobial activity

Arno R.N. Donfack, Ngeh J. Toyang, Hippolyte K. Wabo, Pierre Tane, Maurice D. Awouafack, Haruhisa Kikuchi, Jean D.D. Tamokou, Jules R. Kuiate, Yoshiteru Oshima

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Chemical investigation of the roots of Vernonia guineensis (Asteraceae) afforded a new stigmastane derivative, vernoguinoside A (1) and the known vernoguinoside (2), stigmasterol 3-O-β-d-glucoside (3) and sitosterol 3-O-β-d-glucoside (4). Their structures were elucidated by spectroscopic analysis. Antimicrobial activities of 1-3 and CH 2Cl 2-MeOH (1:1) extract were evaluated against three bacteria species (Salmonella typhi, Staphylococcus aureus and Shigella flexneri) and three yeasts species (Candida albicans, Candida parapsilosis and Cryptococcus neoformans). Compounds 1 and 2 exhibited both antibacterial and antifungal activities that varied between the microbial species (MIC = 7.81-125 μg/mL) while S. flexneri and C. albicans were sensitive to all the tested compounds.

本文言語English
ページ(範囲)596-599
ページ数4
ジャーナルPhytochemistry Letters
5
3
DOI
出版ステータスPublished - 2012 9
外部発表はい

ASJC Scopus subject areas

  • バイオテクノロジー
  • 生化学
  • 農業および作物学
  • 植物科学

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