Strain differences in rat liver UDP-glucuronyltransferase activity towards androsterone

M. Matsui, F. Nagai, S. Aoyagi

研究成果: Article査読

28 被引用数 (Scopus)

抄録

Male Donryu, Wistar and Wistar King rats showed discontinuous variations in hepatic microsomal UDP-glucuronyltransferase activities towards androsterone, but not towards testosterone, bilirubin, phenolphthalein and 4-nitrophenol. Fresh microsomal fraction with a low transferase activity towards androsterone formed 0.049-0.080 nmol of glucuronide/min per mg of protein, whereas fresh microsomal fraction with a high transferase activity towards androsterone formed 0.335-0.557 nmol of glucuronide/min per mg of protein. The microsomal fraction with low enzyme activity towards androsterone was not stimulated by treatment with Triton X-100 or freezing and thawing. In contrast, male Long Evans and Sprague-Dawley rats did not exhibit such diversity.

本文言語English
ページ(範囲)483-487
ページ数5
ジャーナルBiochemical Journal
179
3
DOI
出版ステータスPublished - 1979
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 細胞生物学

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