Strain differences of rat liver carboxylesterase activities related to the phenotype difference of esterase-3 (egasyn)

T. Nakamura, T. Satoh, T. Horie, F. Sagami, O. Tagaya

研究成果: Article査読

4 被引用数 (Scopus)

抄録

It was demonstrated that the inbred strain EHBR had the C phenotype of esterase-3 judging from the absence of liver microsomal β-glucuronidase and the pattern of esterase activities of liver homogenates after analytical isoelectric focusing. In addition, in the strain EHBR, liver microsomal hydrolase activities of acetanilide and isocarboxazid which are hydrolyzed well by esterase-3 were lower than in outbred Sprague-Dawley rat and inbred LEW rat having the D phenotype of esterase-3. These results suggest that the phenotype difference of esterase-3 is possible to cause the strain differences of liver microsomal carboxylesterase activities.

本文言語English
ページ(範囲)451-459
ページ数9
ジャーナルResearch Communications in Chemical Pathology and Pharmacology
66
3
出版ステータスPublished - 1989 12月 1
外部発表はい

ASJC Scopus subject areas

  • 病理学および法医学
  • 毒物学
  • 薬理学
  • 薬理学、毒性学および薬学(全般)

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