Strategies for replacing myocytes with induced pluripotent stem in clinical protocols

Fumiyuki Hattori, Keiichi Fukuda

研究成果: Review article査読

7 被引用数 (Scopus)

抄録

Induced pluripotent stem (iPS) cells can be established via forced epigenetic reprogramming of various somatic cells and selection based on given criteria. Human iPS cells are preferred for clinical applications because they present fewer ethical concerns than embryonic stem cells. However, technical issues of stability and safety must be fully validated before clinical use. Moreover, heart regenerative therapies would require approximately 109 cardiomyocytes per person, necessitating the following technical considerations: (1) genetically and epigenetically stable scaling up of the iPS cells, (2) efficient and reproducible differentiation, and (3) highly reliable cell purification. Furthermore, (4) strategies for efficient iPS transplantation, rapid maturation, and functional integration of grafted cardiomyocytes into the host myocardium are critical unmet technologies. Herein, we discuss current progress and unmet problems for the realization of heart regenerative therapy.

本文言語English
ページ(範囲)223-232
ページ数10
ジャーナルTransplantation Reviews
26
3
DOI
出版ステータスPublished - 2012 7月

ASJC Scopus subject areas

  • 移植

フィンガープリント

「Strategies for replacing myocytes with induced pluripotent stem in clinical protocols」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル