Striatonigral direct pathway activation is sufficient to induce repetitive behaviors

Youcef Bouchekioua, Iku Tsutsui-Kimura, Hiromi Sano, Miwako Koizumi, Kenji F. Tanaka, Keitaro Yoshida, Yutaka Kosaki, Shigeru Watanabe, Masaru Mimura

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Pharmacological intervention in the substantia nigra is known to induce repetitive behaviors in rodents, but a direct causal relationship between a specific neural circuit and repetitive behavior has not yet been established. Here we demonstrate that optogenetic activation of dopamine D1 receptor-expressing MSNs terminals in the substantia nigra pars reticulata resulted in sustained and chronic repetitive behaviors. These data show for the first time that activation of the striatonigral direct pathway is sufficient to generate motor stereotypies.

本文言語English
ページ(範囲)53-57
ページ数5
ジャーナルNeuroscience Research
132
DOI
出版ステータスPublished - 2018 7

ASJC Scopus subject areas

  • Neuroscience(all)

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