Stromal metalloproteinases: Crucial contributors to the tumor microenvironment

Masayuki Shimoda, Takashi Ohtsuka, Yasunori Okada, Yae Kanai

研究成果: Review article査読

1 被引用数 (Scopus)

抄録

Proteolytic balance is crucial for the maintenance of tissue homeostasis. In cancer, dysregulated proteolysis is involved in unregulated tissue remodeling and inflammation, leading to the promotion of tumor growth, local invasion, and metastasis. Metalloproteinases, which were first identified as collagen cleaving enzymes, have been shown to extensively degrade extracellular matrix proteins or selectively release cell surface-bound cytokines, growth factors, or their receptors, thereby impacting extracellular matrix integrity, immune cell recruitment and tissue turnover. Although tumor cells produce various metalloproteinases, the major source is thought to be stromal cells infiltrating the tumor. Different types of stromal cells express specific sets of metalloproteinases and their inhibitors, which specifically alter the milieu within the tumor. In this review, recent findings and knowledge regarding metalloproteinases derived from stromal cells during the creation of the tumor microenvironment are described and their contribution to the tumor progression and metastasis discussed.

本文言語English
ページ(範囲)1-14
ページ数14
ジャーナルPathology international
71
1
DOI
出版ステータスPublished - 2021 1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

フィンガープリント 「Stromal metalloproteinases: Crucial contributors to the tumor microenvironment」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル