Structural basis for species-specific activation of mouse Toll-like receptor 9

Hanako Ishida, Umeharu Ohto, Takuma Shibata, Kensuke Miyake, Toshiyuki Shimizu

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Single-stranded DNA containing unmethylated cytosine-phosphate-guanine (CpG) motifs derived from microorganisms are recognized by Toll-like receptor (TLR) 9 and activate an innate immune response. TLR9 has two DNA-binding sites for CpG DNA and DNA containing cytosine at the second position from the 5′-end; both are required for efficient TLR9 activation in most vertebrate species. However, mouse TLR9 can be dimerized by CpG DNA only, although the underlying mechanism remains elusive. Here, we report the crystal structure of mouse TLR9 complexed with both DNAs. Although most TLR9-CpG DNA interactions are conserved among species, some are unique to mice and involved in species-specificity. These findings provide the structural basis for how mouse TLR9 dimerizes efficiently in response to CpG DNA to activate innate immunity.

本文言語English
ページ(範囲)2636-2646
ページ数11
ジャーナルFEBS Letters
592
15
DOI
出版ステータスPublished - 2018 8月
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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