@article{77fccc2af9ce4b6e92b5b1b318171317,
title = "Structural characterization of y29f mutant of thermoglobin from a hyperthermophilic bacterium aquifex aeolicus",
abstract = "We have determined the crystal structure of thermoglobin (AaTgb) from a hyperthermophilic bacterium Aquifex aeolicus. Tyrosine and glutamine at the B10 and E7 position, respectively, are conserved in AaTgb as are the case of single domain hemoglobins (sdHbs). While the binding affinity of O2 or CO is affected by the replacement of Tyr29 in the distal heme pocket, wild type and Y29F variant of AaTgb show a similar binding affinity of imidazole.",
keywords = "Hemeprotein, Single domain hemoglobin, Thermoglobin",
author = "Norifumi Muraki and Kouta Takeda and Dayeon Nam and Megumi Muraki and Shigetoshi Aono",
note = "Funding Information: Data collections of the crystallographic analyses were performed using the Osaka University beamline BL44XU at SPring-8 under the Collaborative Research Program of Institute for Protein Research, Osaka University (Proposal No. 2019A6953, 2019B6953). We thank Dr. Eiki Yamashita, and Dr. Keisuke Sakurai for their help during data collection. This work was supported by JSPS KAKENHI Grant Numbers JP17H03093 and JP19H05762 to S.A. Publisher Copyright: {\textcopyright} 2021 The Chemical Society of Japan",
year = "2021",
doi = "10.1246/CL.200879",
language = "English",
volume = "50",
journal = "Chemistry Letters",
issn = "0366-7022",
publisher = "Chemical Society of Japan",
number = "4",
}