@article{fd4c4a9aa1df445c95d3e4255e9233f5,
title = "Structural emphysema does not correlate with lung compliance: Lessons from the mouse smoking model",
abstract = "The murine smoke-induced model produces histologic emphysema. The authors sought to assess whether the structural emphysema that occurred correlated with the development of compliance changes. The study exposed 2 strains of mice (CBA/J/Jx C57BL/ 6J and A/J) to chronic cigarette smoke. Lung compliance and morphometry were measured. The smoking model generated significant emphysema in A/J mice in the absence of changes in compliance, lung matrix, or apoptosis. Importantly, there was no correlation between the emphysema measured by lung morphometry and pulmonary compliance. This lack of correlation suggests that the mechanisms involved in anatomic emphysema may be distinct from those that cause the loss of elastic recoil.",
keywords = "Compliance, Emphysema, Morphometry",
author = "Foronjy, {Robert F.} and Mercer, {Becky A.} and Maxfield, {Mark W.} and Powell, {Charles A.} and Jeanine D'Armiento and Yasunori Okada",
note = "Funding Information: Received 4 October 2004; accepted 7 February 2005. The Alpha-1 Antitrypsin Foundation and the Flight Attendant Medical Research Institute provided financial support for this study. The authors like to thank Tina Zelonina for her technical assistance and Dr. Randolph Cole for his critical reading of the manuscript. Address correspondence to Jeanine D{\textquoteright}Armiento, MD, PhD, Department of Medicine, 630 West 168th Street, P&S 8-401, New York, NY 10032, USA. E-mail: jmd12@columbia.edu",
year = "2005",
month = jul,
doi = "10.1080/019021490951522",
language = "English",
volume = "31",
pages = "547--562",
journal = "Experimental Lung Research",
issn = "0190-2148",
publisher = "Informa Healthcare",
number = "6",
}