Structural emphysema does not correlate with lung compliance: Lessons from the mouse smoking model

Robert F. Foronjy, Becky A. Mercer, Mark W. Maxfield, Charles A. Powell, Jeanine D'Armiento, Yasunori Okada

研究成果: Article査読

58 被引用数 (Scopus)

抄録

The murine smoke-induced model produces histologic emphysema. The authors sought to assess whether the structural emphysema that occurred correlated with the development of compliance changes. The study exposed 2 strains of mice (CBA/J/Jx C57BL/ 6J and A/J) to chronic cigarette smoke. Lung compliance and morphometry were measured. The smoking model generated significant emphysema in A/J mice in the absence of changes in compliance, lung matrix, or apoptosis. Importantly, there was no correlation between the emphysema measured by lung morphometry and pulmonary compliance. This lack of correlation suggests that the mechanisms involved in anatomic emphysema may be distinct from those that cause the loss of elastic recoil.

本文言語English
ページ(範囲)547-562
ページ数16
ジャーナルExperimental Lung Research
31
6
DOI
出版ステータスPublished - 2005 7

ASJC Scopus subject areas

  • 分子生物学
  • 呼吸器内科
  • 臨床生化学

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