Structurally simplified zaragozic acid (squalestatin): Stereoselective preparation of a 3,4-unsubstituted derivative

Hisanaka Ito, Miyoko Matsumoto, Takeshi Yoshizawa, Ken Ichi Takao, Susumu Kobayashi

研究成果: Article

17 引用 (Scopus)

抜粋

Stereoselective preparation of a structurally simplified 3,4-unsubstituted zaragozic acid derivative was achieved starting from D-glucose. The present approach involved the stereoselective addition of a vinyl Grignard reagent, selective cleavage of 1,2-diol, and regioselective acylation of the hydroxyl group at C-6.

元の言語English
ページ(範囲)9009-9012
ページ数4
ジャーナルTetrahedron Letters
38
発行部数52
DOI
出版物ステータスPublished - 1997 12 29
外部発表Yes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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