Structurally simplified zaragozic acid (squalestatin): Stereoselective preparation of a 3,4-unsubstituted derivative

Hisanaka Ito, Miyoko Matsumoto, Takeshi Yoshizawa, Kenichi Takao, Susumu Kobayashi

研究成果: Article

17 引用 (Scopus)

抄録

Stereoselective preparation of a structurally simplified 3,4-unsubstituted zaragozic acid derivative was achieved starting from D-glucose. The present approach involved the stereoselective addition of a vinyl Grignard reagent, selective cleavage of 1,2-diol, and regioselective acylation of the hydroxyl group at C-6.

元の言語English
ページ(範囲)9009-9012
ページ数4
ジャーナルTetrahedron Letters
38
発行部数52
出版物ステータスPublished - 1997 12 29
外部発表Yes

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Acylation
Hydroxyl Radical
Derivatives
Glucose
Acids

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

これを引用

Structurally simplified zaragozic acid (squalestatin) : Stereoselective preparation of a 3,4-unsubstituted derivative. / Ito, Hisanaka; Matsumoto, Miyoko; Yoshizawa, Takeshi; Takao, Kenichi; Kobayashi, Susumu.

:: Tetrahedron Letters, 巻 38, 番号 52, 29.12.1997, p. 9009-9012.

研究成果: Article

Ito, Hisanaka ; Matsumoto, Miyoko ; Yoshizawa, Takeshi ; Takao, Kenichi ; Kobayashi, Susumu. / Structurally simplified zaragozic acid (squalestatin) : Stereoselective preparation of a 3,4-unsubstituted derivative. :: Tetrahedron Letters. 1997 ; 巻 38, 番号 52. pp. 9009-9012.
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