Structure-activity relationship of okadaic acid, a potent protein phosphatases PP1 and PP2A inhibitor: 24-epi-okadaic acid and a 18-membered lactone analog

Masaki Kita, Makoto Kuramoto, Tatsuhiko Chiba, Akihiro Yamada, Nobuko Yamada, Takako Ishida, Takeharu Haino, Kaoru Yamada, Yasuharu Ijuin, Osamu Ohno, Daisuke Uemura

研究成果: Article査読

6 被引用数 (Scopus)

抄録

X-Ray crystallographic analysis and structure-activity relationship of okadaic acid revealed that the flexible cavity structure stabilized by intramolecular hydrogen bonds is important for its potent cytotoxicity.

本文言語English
ページ(範囲)1033-1042
ページ数10
ジャーナルHeterocycles
76
2
DOI
出版ステータスPublished - 2008 11 1

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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