Structures and functions of the gut microbial lipidome

Satoshi Morozumi; Masahiro Ueda; Nobuyuki Okahashi; Makoto Arita

doi:10.1016/j.bbalip.2021.159110

Structures and functions of the gut microbial lipidome

Satoshi Morozumi, Masahiro Ueda, Nobuyuki Okahashi, Makoto Arita

薬学科

研究成果: Review article › 査読

2 被引用数 (Scopus)

抄録

Microbial lipids provide signals that are responsible for maintaining host health and controlling disease. The differences in the structures of microbial lipids have been shown to alter receptor selectivity and agonist/antagonist activity. Advanced lipidomics is an emerging field that helps to elucidate the complex bacterial lipid diversity. The use of cutting-edge technologies is expected to lead to the discovery of new functional metabolites involved in host homeostasis. This review aims to describe recent updates on functional lipid metabolites derived from gut microbiota, their structure-activity relationships, and advanced lipidomics technologies.

本文言語	English
論文番号	159110
ジャーナル	Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
巻	1867
号	3
DOI	https://doi.org/10.1016/j.bbalip.2021.159110
出版ステータス	Published - 2022 3月

ASJC Scopus subject areas

分子生物学
細胞生物学

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10.1016/j.bbalip.2021.159110

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引用スタイル

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title = "Structures and functions of the gut microbial lipidome",

abstract = "Microbial lipids provide signals that are responsible for maintaining host health and controlling disease. The differences in the structures of microbial lipids have been shown to alter receptor selectivity and agonist/antagonist activity. Advanced lipidomics is an emerging field that helps to elucidate the complex bacterial lipid diversity. The use of cutting-edge technologies is expected to lead to the discovery of new functional metabolites involved in host homeostasis. This review aims to describe recent updates on functional lipid metabolites derived from gut microbiota, their structure-activity relationships, and advanced lipidomics technologies.",

keywords = "Bioactive lipids, Lipidomics, Microbiome",

author = "Satoshi Morozumi and Masahiro Ueda and Nobuyuki Okahashi and Makoto Arita",

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doi = "10.1016/j.bbalip.2021.159110",

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AU - Ueda, Masahiro

AU - Okahashi, Nobuyuki

AU - Arita, Makoto

N1 - Funding Information: This work was supported by AMED LEAP grant number JP18gm0010003 , JSPS KAKENHI grant numbers 15H05897 , 15H05898 and 20H00495 , AMED grant number JP21ae0121036 , Terumo Life Science Foundation, and JST ERATO grant number JPMJER2101 , Japan. We would like to thank Editage ( www.editage.jp ) for English language editing. Publisher Copyright: © 2022 The Authors

PY - 2022/3

Y1 - 2022/3

N2 - Microbial lipids provide signals that are responsible for maintaining host health and controlling disease. The differences in the structures of microbial lipids have been shown to alter receptor selectivity and agonist/antagonist activity. Advanced lipidomics is an emerging field that helps to elucidate the complex bacterial lipid diversity. The use of cutting-edge technologies is expected to lead to the discovery of new functional metabolites involved in host homeostasis. This review aims to describe recent updates on functional lipid metabolites derived from gut microbiota, their structure-activity relationships, and advanced lipidomics technologies.

AB - Microbial lipids provide signals that are responsible for maintaining host health and controlling disease. The differences in the structures of microbial lipids have been shown to alter receptor selectivity and agonist/antagonist activity. Advanced lipidomics is an emerging field that helps to elucidate the complex bacterial lipid diversity. The use of cutting-edge technologies is expected to lead to the discovery of new functional metabolites involved in host homeostasis. This review aims to describe recent updates on functional lipid metabolites derived from gut microbiota, their structure-activity relationships, and advanced lipidomics technologies.

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KW - Microbiome

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Structures and functions of the gut microbial lipidome

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ASJC Scopus subject areas

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