抄録
We designed the method for prevention of restenosis after balloon angioplasty using laser-induced bubble-collapse acoustic wave. This study was performed to evaluate the effect on smooth muscle cells (SMCs) by Ho:YAG laser (λ=2.10μm)-induced acoustic wave, in vitro and in vivo. The laser energy was delivered by a silica glass fiber into water. Sound pressure was measured with a hydrophone changing the laser energy. The laser-induced acoustic wave was loaded to SMCs in vitro. This acoustic effect on SMCs was measured by MTT assay. The acoustic wave loaded SMCs were controllably injured with the laser energy and laser shots. The balloon denudated rabbit aorta was used to evaluate in vivo effect. The laser-induced acoustic wave loaded aorta was extracted at 42 days after the laser irradiation, and was examined by Hematoxylin-Eosin staining. We found that the laser irradiation of 20 pulses with 60mJ/pulse prevented SMCs proliferation. We think the mechanism of this effect might be same as brachytherapy. We demonstrated the applicability of Ho:YAG laser-induced acoustic wave against vascular restenosis after balloon angioplasty.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 155-161 |
| ページ数 | 7 |
| ジャーナル | Proceedings of SPIE - The International Society for Optical Engineering |
| 巻 | 5319 |
| DOI | |
| 出版ステータス | Published - 2004 10月 27 |
| イベント | Progress in Biomedical Optics and Imaging - Laser Interaction with Tissue and Cells XV - San Jose, CA, United States 継続期間: 2004 1月 26 → 2004 1月 28 |
ASJC Scopus subject areas
- 電子材料、光学材料、および磁性材料
- 凝縮系物理学
- コンピュータ サイエンスの応用
- 応用数学
- 電子工学および電気工学