In order to clarify the role of mucosal endogenous prostaglandin in the healing process of gastric ulcers, gastric mucosal PGE2 and 6-keto PGF1α contents in the healing process were measured in 17 patients with gastric ulcers and these results were compared between H2-blocker therapy and the combination therapy of H2-blocker and sofalcone. 1) Gastric mucosal PGE2 and 6-keto PGF1α contents were not influenced by H2-blocker therapy and these were significantly increased by the combination therapy. 2) Ratio of PAS stain positive areas per total mucosal areas of gastric ulcer scars was not significantly different between the both therapy, but it had a tendency to be higher in the combination therapy. 3) There was a positive correlation between mucosal PGE2 contents of gastric ulcer scars and ratio of PAS stain positive areas per total mucosal areas. In summary, mucosal endogenous PG may play a role of healing process in gastric ulcers.
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