Study on epigenetic differences of monozygotic twin atomic bomb survivors in Hiroshima

Toshihide Harada, Fumiko Ishizaki, Yumiko Nitta, Satomi Aoi, Hiromi Ikeda, Juko Ando, Kohsaku Nitta, Makoto Ito

研究成果: Review article査読

4 被引用数 (Scopus)

抄録

Objective: We investigated the epigenetic differences of monozygotic (MZ) twin atomic bomb (A-bomb) survivors in Hiroshima. Design: A clinical study. Materials and Methods: We analyzed 190 of MZ twin A-bomb survivors who were exposed to A-bomb on 6th August in 1945 in Hiroshima city in Japan. Male of MZ twin A-bomb survivors were 94, and female 96. The number of MZ twin in-utero exposed survivors was 14. For control study, we analyzed 90 brother A-bomb survivors. Results: Most of MZ twin A-bomb survivors were 2 year old at exposure. 24 MZ twin A-bomb survivors died. Mean survival term from exposure was 46.5 years. Main cause of death was malignancy. Liver cancer was the most of malignancy of MZ twin survivors. Conclusions: The epigenetic differences arose during the lifetime of MZ twins of A-bomb survivors. We found that, although MZ twins were epigenetically indistinguishable during the early years of life, older MZ twins exhibited remarkable differences in their overall content and life time with the same experience of A-bomb exposure.

本文言語English
ページ(範囲)258-260
ページ数3
ジャーナルInternational Medical Journal
18
4
出版ステータスPublished - 2011 12月

ASJC Scopus subject areas

  • 医学(全般)

フィンガープリント

「Study on epigenetic differences of monozygotic twin atomic bomb survivors in Hiroshima」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル