Study on parkinson's disease and alcohol drinking

C. Fujii, S. Harada, N. Ohkoshi, A. Hayashi, K. Yoshizawa

研究成果: Article

13 引用 (Scopus)

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To clarify alcohol drinking habits of patients with Parkinson's disease (PD) in Japanese, we compared mean values of alcohol consumption of PD patients and controls with special references to genetic polymorphism of ALDH2. Ninety-three Japanese outpatients with PD (39 males, 54 females) diagnosed by three skilled neurologists from 4 hospitals in Kanto area were analyzed for ALDH2 genotypes and alcohol consumption. A total of 297 healthy controls (156 males, 141 females) in the same area were also analyzed. PCR- SSCP (polymerase chain reaction-single strand conformational change polymorphism) analysis was used to determine ALDH2 genotypes. Mean values of alcohol consumption (ethanol g/month/person) from patients with PD were estimated by direct interview, and those from controls were obtained by questionnaire. Distributions of three genotypes and allele frequencies of ALDH2 were not different between patients and controls, however mean values of alcohol consumption of PD group were significantly lower than those of control group when compared between the same ALDH2 genotype. Our data suggested that the lower values of alcohol consumption in patients with PD for every ALDH2 genotypes may be caused by other factors such as premorbid personality rather than ALDH2 variant.

元の言語English
ページ(範囲)683-691
ページ数9
ジャーナルJapanese Journal of Alcohol Studies and Drug Dependence
33
発行部数6
出版物ステータスPublished - 1998 12 1
外部発表Yes

ASJC Scopus subject areas

  • Medicine(all)

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  • これを引用

    Fujii, C., Harada, S., Ohkoshi, N., Hayashi, A., & Yoshizawa, K. (1998). Study on parkinson's disease and alcohol drinking. Japanese Journal of Alcohol Studies and Drug Dependence, 33(6), 683-691.