Study on parkinson's disease and alcohol drinking

Chieko Fujii, S. Harada, N. Ohkoshi, A. Hayashi, K. Yoshizawa

研究成果: Article

13 引用 (Scopus)

抄録

To clarify alcohol drinking habits of patients with Parkinson's disease (PD) in Japanese, we compared mean values of alcohol consumption of PD patients and controls with special references to genetic polymorphism of ALDH2. Ninety-three Japanese outpatients with PD (39 males, 54 females) diagnosed by three skilled neurologists from 4 hospitals in Kanto area were analyzed for ALDH2 genotypes and alcohol consumption. A total of 297 healthy controls (156 males, 141 females) in the same area were also analyzed. PCR- SSCP (polymerase chain reaction-single strand conformational change polymorphism) analysis was used to determine ALDH2 genotypes. Mean values of alcohol consumption (ethanol g/month/person) from patients with PD were estimated by direct interview, and those from controls were obtained by questionnaire. Distributions of three genotypes and allele frequencies of ALDH2 were not different between patients and controls, however mean values of alcohol consumption of PD group were significantly lower than those of control group when compared between the same ALDH2 genotype. Our data suggested that the lower values of alcohol consumption in patients with PD for every ALDH2 genotypes may be caused by other factors such as premorbid personality rather than ALDH2 variant.

元の言語English
ページ(範囲)683-691
ページ数9
ジャーナルJapanese Journal of Alcohol Studies and Drug Dependence
33
発行部数6
出版物ステータスPublished - 1998
外部発表Yes

Fingerprint

Alcohol Drinking
Parkinson Disease
alcohol consumption
alcohol
Disease
Genotype
alcohol consumption habits
Single-Stranded Conformational Polymorphism
Polymerase Chain Reaction
Genetic Polymorphisms
Gene Frequency
Habits
Personality
personality
Ethanol
Outpatients
Group
Interviews
Control Groups
human being

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Health(social science)

これを引用

Fujii, C., Harada, S., Ohkoshi, N., Hayashi, A., & Yoshizawa, K. (1998). Study on parkinson's disease and alcohol drinking. Japanese Journal of Alcohol Studies and Drug Dependence, 33(6), 683-691.

Study on parkinson's disease and alcohol drinking. / Fujii, Chieko; Harada, S.; Ohkoshi, N.; Hayashi, A.; Yoshizawa, K.

:: Japanese Journal of Alcohol Studies and Drug Dependence, 巻 33, 番号 6, 1998, p. 683-691.

研究成果: Article

Fujii, C, Harada, S, Ohkoshi, N, Hayashi, A & Yoshizawa, K 1998, 'Study on parkinson's disease and alcohol drinking', Japanese Journal of Alcohol Studies and Drug Dependence, 巻. 33, 番号 6, pp. 683-691.
Fujii, Chieko ; Harada, S. ; Ohkoshi, N. ; Hayashi, A. ; Yoshizawa, K. / Study on parkinson's disease and alcohol drinking. :: Japanese Journal of Alcohol Studies and Drug Dependence. 1998 ; 巻 33, 番号 6. pp. 683-691.
@article{a70bf218b5d44a0aa23cc5d58427e449,
title = "Study on parkinson's disease and alcohol drinking",
abstract = "To clarify alcohol drinking habits of patients with Parkinson's disease (PD) in Japanese, we compared mean values of alcohol consumption of PD patients and controls with special references to genetic polymorphism of ALDH2. Ninety-three Japanese outpatients with PD (39 males, 54 females) diagnosed by three skilled neurologists from 4 hospitals in Kanto area were analyzed for ALDH2 genotypes and alcohol consumption. A total of 297 healthy controls (156 males, 141 females) in the same area were also analyzed. PCR- SSCP (polymerase chain reaction-single strand conformational change polymorphism) analysis was used to determine ALDH2 genotypes. Mean values of alcohol consumption (ethanol g/month/person) from patients with PD were estimated by direct interview, and those from controls were obtained by questionnaire. Distributions of three genotypes and allele frequencies of ALDH2 were not different between patients and controls, however mean values of alcohol consumption of PD group were significantly lower than those of control group when compared between the same ALDH2 genotype. Our data suggested that the lower values of alcohol consumption in patients with PD for every ALDH2 genotypes may be caused by other factors such as premorbid personality rather than ALDH2 variant.",
keywords = "Alcohol consumption, ALDH2 genotypes, Dislike to alcohol, Parkinson's disease, Premorbid personality",
author = "Chieko Fujii and S. Harada and N. Ohkoshi and A. Hayashi and K. Yoshizawa",
year = "1998",
language = "English",
volume = "33",
pages = "683--691",
journal = "Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence",
issn = "1341-8963",
publisher = "Nihon Arukoru Igakkai/Japenese Medical Society of Alcohol Studies",
number = "6",

}

TY - JOUR

T1 - Study on parkinson's disease and alcohol drinking

AU - Fujii, Chieko

AU - Harada, S.

AU - Ohkoshi, N.

AU - Hayashi, A.

AU - Yoshizawa, K.

PY - 1998

Y1 - 1998

N2 - To clarify alcohol drinking habits of patients with Parkinson's disease (PD) in Japanese, we compared mean values of alcohol consumption of PD patients and controls with special references to genetic polymorphism of ALDH2. Ninety-three Japanese outpatients with PD (39 males, 54 females) diagnosed by three skilled neurologists from 4 hospitals in Kanto area were analyzed for ALDH2 genotypes and alcohol consumption. A total of 297 healthy controls (156 males, 141 females) in the same area were also analyzed. PCR- SSCP (polymerase chain reaction-single strand conformational change polymorphism) analysis was used to determine ALDH2 genotypes. Mean values of alcohol consumption (ethanol g/month/person) from patients with PD were estimated by direct interview, and those from controls were obtained by questionnaire. Distributions of three genotypes and allele frequencies of ALDH2 were not different between patients and controls, however mean values of alcohol consumption of PD group were significantly lower than those of control group when compared between the same ALDH2 genotype. Our data suggested that the lower values of alcohol consumption in patients with PD for every ALDH2 genotypes may be caused by other factors such as premorbid personality rather than ALDH2 variant.

AB - To clarify alcohol drinking habits of patients with Parkinson's disease (PD) in Japanese, we compared mean values of alcohol consumption of PD patients and controls with special references to genetic polymorphism of ALDH2. Ninety-three Japanese outpatients with PD (39 males, 54 females) diagnosed by three skilled neurologists from 4 hospitals in Kanto area were analyzed for ALDH2 genotypes and alcohol consumption. A total of 297 healthy controls (156 males, 141 females) in the same area were also analyzed. PCR- SSCP (polymerase chain reaction-single strand conformational change polymorphism) analysis was used to determine ALDH2 genotypes. Mean values of alcohol consumption (ethanol g/month/person) from patients with PD were estimated by direct interview, and those from controls were obtained by questionnaire. Distributions of three genotypes and allele frequencies of ALDH2 were not different between patients and controls, however mean values of alcohol consumption of PD group were significantly lower than those of control group when compared between the same ALDH2 genotype. Our data suggested that the lower values of alcohol consumption in patients with PD for every ALDH2 genotypes may be caused by other factors such as premorbid personality rather than ALDH2 variant.

KW - Alcohol consumption

KW - ALDH2 genotypes

KW - Dislike to alcohol

KW - Parkinson's disease

KW - Premorbid personality

UR - http://www.scopus.com/inward/record.url?scp=0032432156&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032432156&partnerID=8YFLogxK

M3 - Article

C2 - 10028826

AN - SCOPUS:0032432156

VL - 33

SP - 683

EP - 691

JO - Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence

JF - Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence

SN - 1341-8963

IS - 6

ER -