Substrate specificity of an esterase from the archaeon Sulfolobus tokodaii bearing a GGG(A)X motif

Reina Wada, Masanaru Ozaki, Takashi Kumon, Hiromichi Ohta, Kenji Miyamoto

研究成果: Article査読

1 被引用数 (Scopus)

抄録

A GGG(A)X-type esterase (Est0071) from an archaeon catalyzes asymmetric hydrolysis of prochiral bulky malonic diesters in good enantioselectivity. The selectivity of Est0071 was for the opposite enantiomer to that previously shown for pig liver esterase, and the resulting enantiomeric excess of the products was higher. Est0071 could also catalyze the hydrolysis of various acetates of secondary alcohols, and showed moderate enantioselectivity in these reactions.

本文言語English
ページ(範囲)188-190
ページ数3
ジャーナルBiocatalysis and Biotransformation
33
3
DOI
出版ステータスPublished - 2015 5 4

ASJC Scopus subject areas

  • バイオテクノロジー
  • 触媒
  • 生化学

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