Successful preparation of metabolite of troglitazone by in-flow electrochemical reaction on coulometric electrode

Kayoko Tahara, Yuka Yano, Kiyotada Kanagawa, Yoshihiro Abe, Junko Yamada, Shiro Iijima, Masataka Mochizuki, Takashi Nishikawa

研究成果: Article査読

22 被引用数 (Scopus)

抄録

A simple, rapid and efficient system utilizing a coulometric electrode was developed for the preparation of drug metabolites. Trace amounts of reactants are usually generated in electrochemical reactions, which are not suitable for the sufficient preparation of products to obtain NMR and other spectral data for chemical structure confirmation or to obtain data from pharmacological activity screening tests of products. In the developed system, called the "in-flow electrochemical reaction system," a drug, troglitazone, was dissolved in a volatile flow solvent, and pumped into a coulometric electrode under optimized conditions, and the effluent was evaporated. Without any further purification, milligram amounts of a pure oxidation product of troglitazone could be obtained within several hours. The amount obtained was enough for 1H- and 13C-NMR analysis by which the structure could be confirmed and was found to be identical to one of the metabolites of troglitazone detected in human plasma. This system will be useful to prepare standard compounds of the required amount for pharmacokinetic study and for toxicokinetic study.

本文言語English
ページ(範囲)1207-1212
ページ数6
ジャーナルChemical and Pharmaceutical Bulletin
55
8
DOI
出版ステータスPublished - 2007 8月

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

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