Successful thrombolysis without hemorrhage in a patient with cardioembolic stroke under dabigatran treatment - A case report and review of literature

Jun Inaishi, Shigeru Nogawa, Yoshinori Mano, Takahito Yoshizaki, Satoshi Okada

研究成果: Article査読

6 被引用数 (Scopus)

抄録

A 72-year-old male with heart failure was admitted to our hospital. Treatment with dabigatran (220 mg per day) was initiated because of atrial fibrillation. On the third day, the patient developed left-sided hemiparesis and dysarthria at 4.5 hr after the last dose of dabigatran. The activated partial thromboplastin time (APTT) was 39.1 sec, and the NIHSS (NIH Stroke Scale) was 11. An intravenous infusion of rt-PA was administered at 160 min after the onset of hemiparesis (at 7 hr after the last dose of dabigatran). Although diffusion weighted MRI revealed a minor infarction in the right lower frontal gyrus, the patient was discharged without hemorrhage (NIHSS 0), and the score on the modified Rankin scale assessed 3 months later was 0. The outcomes have been good in 8 out of 9 reported cases, including the present case; the remaining severe case developed complicating intracranial hemorrhage. Thrombolytic therapy could be safe, if it is performed more than 7 hr after the last dose of dabigatran and the APTT is less than 40 sec.

本文言語English
ページ(範囲)238-240
ページ数3
ジャーナルClinical Neurology
54
3
DOI
出版ステータスPublished - 2014 3月
外部発表はい

ASJC Scopus subject areas

  • 臨床神経学

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