Successful treatment of dopamine dysregulation syndrome with dopamine D 2 partial agonist antipsychotic drug

Jin Mizushima, Keisuke Takahata, Noriko Kawashima, Motoichiro Kato

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Dopamine dysregulation syndrome (DDS) consists of a series of complications such as compulsive use of dopaminergic medications, aggressive or hypomanic behaviors during excessive use, and withdrawal states characterized by dysphoria and anxiety, caused by long-term dopaminergic treatment in patients with Parkinson's disease (PD). Although several ways to manage DDS have been suggested, there has been no established treatment that can manage DDS without deterioration of motor symptoms. In this article, we present a case of PD in whom the administration of the dopamine D 2 partial agonistic antipsychotic drug aripiprazole improved DDS symptoms such as craving and compulsive behavior without worsening of motor symptoms. Considering the profile of this drug as a partial agonist at D 2 receptors, it is possible that it exerts its therapeutic effect on DDS by modulating the dysfunctional dopamine system.

本文言語English
論文番号19
ジャーナルAnnals of General Psychiatry
11
DOI
出版ステータスPublished - 2012 7月 7
外部発表はい

ASJC Scopus subject areas

  • 精神医学および精神衛生

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