Successful treatment of young-onset adult T cell leukemia/lymphoma and preceding chronic refractory eczema and corneal injury by allogeneic hematopoietic stem cell transplantation

Fumiya Miyamura, Shinichi Kako, Hiroko Yamagami, Ken Sato, Miki Sato, Kiriko Terasako, Shun Ichi Kimura, Hideki Nakasone, Satoko Aoki, Shinya Okuda, Rie Yamazaki, Kumi Oshima, Kentaro Yoshinaga, Takakazu Higuchi, Junji Nishida, Toshio Demitsu, Akihiro Kakehashi, Yoshinobu Kanda

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Only some carriers of human T cell lymphotropic virus type I (HTLV-1) develop adult T cell leukemia/lymphoma (ATLL) after a long latency period, and an association has been reported between chronic refractory eczema, known as infective dermatitis, and young-onset ATLL. A 25-year-old female developed ATLL and underwent allogeneic hematopoietic stem cell transplantation (HSCT) in non-remission. She had chronic refractory eczema and corneal injury at the onset of ATLL. Remission of ATLL was achieved, and the HTLV-1 proviral load decreased after HSCT. In addition, her pre-existing eczema and corneal injuries almost disappeared. More than a year has passed since the transplantation was performed, and she has had no recurrence of either ATLL or lesions in the skin and eye. Her clinical course suggests a possible association between skin and eye lesions and HTLV-1 infection. Changes in the immunological condition after HSCT might play a key role. Special attention is needed when HTLV-1 carriers develop eye or skin lesions.

本文言語English
ページ(範囲)397-401
ページ数5
ジャーナルInternational journal of hematology
90
3
DOI
出版ステータスPublished - 2009 10
外部発表はい

ASJC Scopus subject areas

  • 血液学

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