重症筋無力症,全身性エリテマトーデス,関節リウマチを合併した外陰部悪性黒色腫に対してニボルマブ投与と放射線療法が奏功した 1 例

Asako Ota, Reika Aoyama, Atsushi Tanemura, Yorihisa Kotobuki, Ichiro Katayama, Keita Kakuta, Kohei Tsujimoto, Toshiro Tanaka, Shigeaki Suzuki

研究成果: Article

抄録

A woman in her 50s had myasthenia gravis (MG), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE). Enlargement resection and colostomy were performed for malignant anal melanoma (Stage IB T1bN 0 M 0). There was no recurrence during the follow-up period. Three years later, she developed pain and bleeding from the vulva. As an irregular black-colored macule and nodules in the vagina and external urethral meatus were observed separately from the surgical margin, recurrence from eld cells was suspected. We found a large unresectable mass that had directly invaded the urethra and remained in the rectum, and initiated concurrent irradiation and nivolumab treatment. After the 15th administration of nivolumab and 45 Gy of irradiation, the tumor had markedly decreased in size without any new metastatic lesions. The antitumor mechanism is considered to be via abscopal and synergistic effects, as demonstrated by increased PD-L1 expression. However, there are few case reports of combination therapy of nivolumab and radiotherapy for malignant melanoma in Japan.

元の言語Japanese
ページ(範囲)62-69
ページ数8
ジャーナルSkin research
17
発行部数2
DOI
出版物ステータスPublished - 2018 1 1

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Autoimmune Diseases
Radiotherapy
Melanoma
Psychosexual Development
Recurrence
Colostomy
Vulva
Myasthenia Gravis
Vagina
Urethra
Rectum
Systemic Lupus Erythematosus
Rheumatoid Arthritis
Japan
Therapeutics
Hemorrhage
Pain
nivolumab
Neoplasms
Margins of Excision

Keywords

  • Anti-PD1 antibody
  • Malignant melanoma
  • Myasthenia gravis
  • Radiotherapy

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

これを引用

重症筋無力症,全身性エリテマトーデス,関節リウマチを合併した外陰部悪性黒色腫に対してニボルマブ投与と放射線療法が奏功した 1 例. / Ota, Asako; Aoyama, Reika; Tanemura, Atsushi; Kotobuki, Yorihisa; Katayama, Ichiro; Kakuta, Keita; Tsujimoto, Kohei; Tanaka, Toshiro; Suzuki, Shigeaki.

:: Skin research, 巻 17, 番号 2, 01.01.2018, p. 62-69.

研究成果: Article

Ota, Asako ; Aoyama, Reika ; Tanemura, Atsushi ; Kotobuki, Yorihisa ; Katayama, Ichiro ; Kakuta, Keita ; Tsujimoto, Kohei ; Tanaka, Toshiro ; Suzuki, Shigeaki. / 重症筋無力症,全身性エリテマトーデス,関節リウマチを合併した外陰部悪性黒色腫に対してニボルマブ投与と放射線療法が奏功した 1 例. :: Skin research. 2018 ; 巻 17, 番号 2. pp. 62-69.
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