18O incorporation from H218O2 in the oxidation of N-methylcarbazole and sulfides catalyzed by microperoxidase-11

Shigeo Nakamura, Tadahiko Mashino, Masaaki Hirobe

研究成果: Article査読

34 被引用数 (Scopus)

抄録

Microperoxidase-11 (MP-11), prepared by pepsin digestion of cytochrome c, contains protoheme IX and one proximal histidine ligand. MP-11 oxygenated N-methylcarbazole, methyl phenyl sulfide, and phenacyl phenyl sulfide with 80%, 100%, and 96% 18O atom incorporation from H218O2, respectively. These results indicate that the oxygen atom on heme iron of MP-11 immediately rebinds to one-electron-oxidized intermediates of the substrates and that MP-11 catalyzes N-demethylation through a cytochrome P-450-like mechanism rather than a peroxidase-like mechanism.

本文言語English
ページ(範囲)5409-5412
ページ数4
ジャーナルTetrahedron Letters
33
37
DOI
出版ステータスPublished - 1992 9 8
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

フィンガープリント

「<sup>18</sup>O incorporation from H<sub>2</sub><sup>18</sup>O<sub>2</sub> in the oxidation of N-methylcarbazole and sulfides catalyzed by microperoxidase-11」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル