18O incorporation from H218O2 in the oxidation of N-methylcarbazole and sulfides catalyzed by microperoxidase-11

Shigeo Nakamura, Tadahiko Mashino, Masaaki Hirobe

研究成果: Article

34 引用 (Scopus)

抜粋

Microperoxidase-11 (MP-11), prepared by pepsin digestion of cytochrome c, contains protoheme IX and one proximal histidine ligand. MP-11 oxygenated N-methylcarbazole, methyl phenyl sulfide, and phenacyl phenyl sulfide with 80%, 100%, and 96% 18O atom incorporation from H218O2, respectively. These results indicate that the oxygen atom on heme iron of MP-11 immediately rebinds to one-electron-oxidized intermediates of the substrates and that MP-11 catalyzes N-demethylation through a cytochrome P-450-like mechanism rather than a peroxidase-like mechanism.

元の言語English
ページ(範囲)5409-5412
ページ数4
ジャーナルTetrahedron Letters
33
発行部数37
DOI
出版物ステータスPublished - 1992 9 8
外部発表Yes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

フィンガープリント <sup>18</sup>O incorporation from H<sub>2</sub><sup>18</sup>O<sub>2</sub> in the oxidation of N-methylcarbazole and sulfides catalyzed by microperoxidase-11' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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