Super-enhancer switching drives a burst in gene expression at the mitosis-to-meiosis transition

So Maezawa, Akihiko Sakashita, Masashi Yukawa, Xiaoting Chen, Kazuki Takahashi, Kris G. Alavattam, Ippo Nakata, Matthew T. Weirauch, Artem Barski, Satoshi H. Namekawa

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Owing to bursts in the expression of thousands of germline-specific genes, the testis has the most diverse and complex transcriptome of all organs. By analyzing the male germline of mice, we demonstrate that the genome-wide reorganization of super-enhancers (SEs) drives bursts in germline gene expression after the mitosis-to-meiosis transition. SE reorganization is regulated by two molecular events: the establishment of meiosis-specific SEs via A-MYB (MYBL1), a key transcription factor for germline genes, and the resolution of SEs in mitotically proliferating cells via SCML2, a germline-specific Polycomb protein required for spermatogenesis-specific gene expression. Before entry into meiosis, meiotic SEs are preprogrammed in mitotic spermatogonia to ensure the unidirectional differentiation of spermatogenesis. We identify key regulatory factors for both mitotic and meiotic enhancers, revealing a molecular logic for the concurrent activation of mitotic enhancers and suppression of meiotic enhancers in the somatic and/or mitotic proliferation phases.

本文言語English
ページ(範囲)978-988
ページ数11
ジャーナルNature Structural and Molecular Biology
27
10
DOI
出版ステータスPublished - 2020 10 1

ASJC Scopus subject areas

  • 構造生物学
  • 分子生物学

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