Superoxide radical initiates the autoxidation of dihydroxyacetone

Tadahiko Mashino, Irwin Fridovich

研究成果: Article

39 被引用数 (Scopus)

抄録

The aerobic xanthine oxidase reaction causes the cooxidation of dihydroxyacetone in a process which is strongly inhibited by superoxide dismutase but not by catalase, HO · scavengers, or iron-inactivating chelating agents. Several molecules of the sugar can be oxidized per O2- introduced. A free radical chain mechanism, in which O2- acts both as an initiator and as a chain propagator, is proposed. Simple sugars capable of tautomerizing to enediols may now be added to the list of biologically relevant targets for O2-.

本文言語English
ページ(範囲)547-551
ページ数5
ジャーナルArchives of Biochemistry and Biophysics
254
2
DOI
出版ステータスPublished - 1987 5 1
外部発表はい

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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