Suppression of ethanol-induced apoptotic DNA fragmentation by geranylgeranylacetone in cultured guinea pig gastric mucosal cells

Tohru Mizushima, Shinji Tsutsumi, Kazuhito Rokutan, Tomofusa Tsuchiya

研究成果: Article査読

43 被引用数 (Scopus)

抄録

The purpose of this study was to elucidate the molecular mechanism of action of geranylgeranylacetone, an antiulcer drug. Treatment with ethanol for 8 hr at the optimum concentration (7.5%) caused apoptotic DNA fragmentation in cultured guinea pig gastric mucosal cells. Pretreatment of cells with geranylgeranylacetone suppressed the DNA fragmentation in a dose- dependent manner. The maximum effect was achieved at 10-6 M, at which concentration the drug was previously shown to induce heat-shock proteins. The suppression required an incubation period longer than 1 hr. Pretreatment of cells with low concentrations of ethanol also prevented DNA fragmentation.

本文言語English
ページ(範囲)510-514
ページ数5
ジャーナルDigestive Diseases and Sciences
44
3
DOI
出版ステータスPublished - 1999
外部発表はい

ASJC Scopus subject areas

  • 生理学
  • 消化器病学

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