Suppression of in Vitro Granulocyte‐Macrophage Colony Formation by the Peripheral Mononuclear Phagocytic Cells of Patients with Idiopathic Aplastic Anaemia

Toshio Suda, Hideaki Mizoguchi, Yasusada Miura, Kazuo Kubota, Fumimaro Takaku

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Summary. To investigate whether phagocytic cells play a role in the pathogenesis of aplastic anaemia, we studied the effect of the mononuclear phagocytic cells in the peripheral blood from patients with idiopathic aplastic anaemia on granulocyte—macrophage colony (GM‐colony) formation. There was no apparent infection in the studied patients. In nine out of 20 cases the mononuclear cells suppressed the formation of GM‐colonies by normal bone marrow. Removal of the phagocytic cells by carbonyl iron powder caused a loss of this suppressive effect. These results suggest the requirement for phagocytic cells in this suppressive effect and the possible involvement of phagocyte‐mediated immunological mechanism in the pathogenesis of some cases of idiopathic aplastic anaemia.

本文言語English
ページ(範囲)433-442
ページ数10
ジャーナルBritish Journal of Haematology
47
3
DOI
出版ステータスPublished - 1981 3

ASJC Scopus subject areas

  • Hematology

フィンガープリント 「Suppression of in Vitro Granulocyte‐Macrophage Colony Formation by the Peripheral Mononuclear Phagocytic Cells of Patients with Idiopathic Aplastic Anaemia」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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