Suppression of multidrug resistance by migrastatin

Yasushi Takemoto, Etsu Tashiro, Masaya Imoto

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Migrastatin (MGS) is a Streptomyces metabolite that inhibits cancer cell migration. In this study, we found that MGS also enhanced the cytotoxicity of vinblastine, vincristine, and taxol in P-glycoprotein-overexpressing VJ-300 cells and P388/VCR cells. Furthermore, MGS increased the intracellular concentration of labeled vinblastine, vincristine, and taxol in both VJ-300 cells and P388/VCR cells. P-glycoprotein was photolabeled with [ 3H]azidopine, but this photolabeling was significantly inhibited in the presence of MGS. These results indicated that MGS directly interacts with and inhibits P-glycoprotein, thereby sensitizing drug-resistant cells to anticancer drugs.

本文言語English
ページ(範囲)435-438
ページ数4
ジャーナルJournal of Antibiotics
59
7
DOI
出版ステータスPublished - 2006 7

ASJC Scopus subject areas

  • 薬理学
  • 創薬

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