Susceptibility of tenascin to degradation by matrix metalloproteinases and serine proteinases

Kazushi Imai, Moriaki Kusakabe, Teruyo Sakakura, Isao Nakanishi, Yasunori Okada

研究成果: Article査読

70 被引用数 (Scopus)

抄録

The degradation of tenascin purified from human melanoma cells was examined by treatment with matrix metalloproteinases (MMPs) and serine proteinases. Among eight different types of proteinases examined, MMP-1, -3, and -7, cathepsin G and leukocyte elastase could digest tenascin, but MMP-2, MMP-9 and thrombin did not. This suggests that tenascin may be readily catabolized by extracellular matrix-degrading proteinases found in the pathophysiological conditions.

本文言語English
ページ(範囲)216-218
ページ数3
ジャーナルFEBS Letters
352
2
DOI
出版ステータスPublished - 1994 9月 26
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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