Sustained monomorphic ventricular tachycardia in a patient with Brugada syndrome

Megumi Shimada, Toshihisa Miyazaki, Shunichiro Miyoshi, Kyoko Soejima, Shingo Hori, Hideo Mitamura, Satoshi Ogawa

研究成果: Article査読

68 被引用数 (Scopus)

抄録

We report a patient with Brugada syndrome who developed sustained monomorphic ventricular tachycardia (SMVT). The patient was a 29-year-old man who experienced recurrent episodes of palpitation and syncope after drinking alcohol. Electrocardiogram showed right bundle branch block and ST-segment elevation in precordial leads V(1-3) without Q-Tc prolongation. Organic heart disease and coronary artery disease were excluded by noninvasive and invasive tests. Ventricular fibrillation was induced by the application of a single extrastimulus to the right ventricular outflow tract. During isoproterenol infusion. SMVT of left bundle branch block morphology (240/min) was induced by the application of a single extrastimulus to the right ventricular apex. SMVT also developed spontaneously. Pace mapping disclosed that SMVT originated at the free wall of the right ventricular outflow tract. Head-up tilt test and an alcohol provocation test both induced similar SMVT that was associated with hypotension and near syncope. SMVT was not terminated by intravenous administration of lidocaine, procainamide or adenosine triphosphate (10 mg), but was terminated by propranolol. Thus, a beta- adrenoceptor-mediated mechanisms appears to play an important role in SMVT in this patient. The site of origin of SMVT might be closely related to the lesion that causes ST-segment elevation.

本文言語English
ページ(範囲)364-370
ページ数7
ジャーナルJAPANESE CIRCULATION JOURNAL
60
6
DOI
出版ステータスPublished - 1996 6 1

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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