Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells

Guligena Tuerdi, Saki Ichinomiya, Hiromi Sato, Sana Siddig, Eriko Suwa, Hiroki Iwata, Tomohiro Yano, Koichi Ueno

研究成果: Article査読

12 被引用数 (Scopus)

抄録

The present study is the first to demonstrate the synergetic effect of statins (atorvastatin and simvastatin) and gamma-tocotrienol (γ-T3) on human malignant mesothelioma (MM). Statin + γ-T3 combinations induced greater cell growth inhibition more than each single treatment via inhibition of mevalonate pathway, a well-known target of both γ-T3 and statins. γ-T3 was necessary for endoplasmic reticulum stress markers CHOP and GRP78, whereas an intrinsic apoptotic marker, caspase 3 activation was induced only in the presence of statins. Overall, the combination of γ-T3 and statins could be useful for MM therapy and functions in a complementary style.

本文言語English
ページ(範囲)116-127
ページ数12
ジャーナルCancer Letters
339
1
DOI
出版ステータスPublished - 2013 10 1
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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