Synthesis and antimicrobial properties of amphiphilic sugar derivatives containing sulfur and nitrogen

K. Yago, S. Zen, K. Kawada, T. Uchibori, K. Asakura, S. Matsumura

研究成果: Article査読

抄録

Two series of methyl α-D-glucoside derivatives containing an alkyl chain with 8 to 16 atoms, methyl 6-N-alkylamino-6-deoxy-α-D-glucoside and methyl 6-alkylthio-6-deoxy-α-D-glucoside, were synthesized and their antimicrobial activities were evaluated. All of the compounds tested were found to show inhibitory activities, and these activities were dependent on alkyl chain length. In particular, methyl α-D-glucoside derivatives with a dodecyl group showed considerable inhibitory activity. Among the dodecyl derivatives, the sulfur derivative was more effective than the imino derivative.

本文言語English
ページ(範囲)213-216
ページ数4
ジャーナルJournal of Antibacterial and Antifungal Agents, Japan
22
4
出版ステータスPublished - 1994
外部発表はい

ASJC Scopus subject areas

  • 微生物学

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