抄録
Synthesis of the indenotryptoline bisindole alkaloid, BE-54017, was accomplished using osmium-promoted cis-dihydroxylation of maleimide as a key step. After optical resolution, the absolute configuration of this molecule was determined by comparing its optical rotation and HPLC profile to those obtained for BE-54017 derived from enantiopure cladoniamide A, whose stereochemistry has been reported previously. BE-54017 with the correct absolute stereochemistry induced apoptosis of epidermal growth factor (EGF)-stimulated EGF receptor overexpressing A431 cells and inhibited vacuolar-type H+-ATPase (V-ATPase).
| 本文言語 | English |
|---|---|
| ページ（範囲） | 4418-4421 |
| ページ数 | 4 |
| ジャーナル | Organic Letters |
| 巻 | 14 |
| 号 | 17 |
| DOI | |
| 出版ステータス | Published - 2012 9 7 |
ASJC Scopus subject areas
- 生化学
- 物理化学および理論化学
- 有機化学