抜粋
Synthesis of the indenotryptoline bisindole alkaloid, BE-54017, was accomplished using osmium-promoted cis-dihydroxylation of maleimide as a key step. After optical resolution, the absolute configuration of this molecule was determined by comparing its optical rotation and HPLC profile to those obtained for BE-54017 derived from enantiopure cladoniamide A, whose stereochemistry has been reported previously. BE-54017 with the correct absolute stereochemistry induced apoptosis of epidermal growth factor (EGF)-stimulated EGF receptor overexpressing A431 cells and inhibited vacuolar-type H+-ATPase (V-ATPase).
| 元の言語 | English |
|---|---|
| ページ（範囲） | 4418-4421 |
| ページ数 | 4 |
| ジャーナル | Organic Letters |
| 巻 | 14 |
| 発行部数 | 17 |
| DOI | |
| 出版物ステータス | Published - 2012 9 7 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
フィンガープリント Synthesis and assignment of the absolute configuration of indenotryptoline bisindole alkaloid BE-54017' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。
これを引用
Kimura, T., Kanagaki, S., Matsui, Y., Imoto, M., Watanabe, T., & Shibasaki, M. (2012). Synthesis and assignment of the absolute configuration of indenotryptoline bisindole alkaloid BE-54017. Organic Letters, 14(17), 4418-4421. https://doi.org/10.1021/ol3019314